CHIR-265

Ligand id: 5674

Name: CHIR-265

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 80.65
Molecular weight 518.13
XLogP 7.09
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Large-scale screening data

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,4

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action Affinity Units
discoidin domain receptor tyrosine kinase 1 DDR1 Hs Inhibitor Inhibition 7.9 pKd
EPH receptor B6 EPHB6 Hs Inhibitor Inhibition 7.4 pKd
mitogen-activated protein kinase kinase kinase 19 YSK4 Hs Inhibitor Inhibition 7.3 pKd
eukaryotic translation initiation factor 2 alpha kinase 4 GCN2(Kin.Dom.2,S808G) Hs Inhibitor Inhibition 7.3 pKd
serine/threonine kinase 10 LOK Hs Inhibitor Inhibition 7.2 pKd
ZAK sterile alpha motif and leucine zipper containing kinase AZK ZAK Hs Inhibitor Inhibition 7.2 pKd
ret proto-oncogene RET(M918T) Hs Inhibitor Inhibition 7.1 pKd
KIT proto-oncogene receptor tyrosine kinase KIT(L576P) Hs Inhibitor Inhibition 7.1 pKd
citron rho-interacting serine/threonine kinase CIT Hs Inhibitor Inhibition 7.1 pKd
ret proto-oncogene RET(V804M) Hs Inhibitor Inhibition 7.1 pKd
Displaying the top 10 targets  View all targets in screen »