enzastaurin

Ligand id: 5693

Name: enzastaurin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 72.16
Molecular weight 515.23
XLogP 5.36
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Large-scale screening data

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,5

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action Affinity Units
glycogen synthase kinase 3 beta GSK3B Hs Inhibitor Inhibition 8.1 pKd
protein kinase C epsilon PRKCE Hs Inhibitor Inhibition 8.1 pKd
protein kinase C delta PRKCD Hs Inhibitor Inhibition 7.6 pKd
ribosomal protein S6 kinase A6 RSK4(Kin.Dom.1-N-terminal) Hs Inhibitor Inhibition 7.6 pKd
protein kinase C theta PRKCQ Hs Inhibitor Inhibition 7.4 pKd
fms related tyrosine kinase 3 FLT3(D835Y) Hs Inhibitor Inhibition 7.4 pKd
protein kinase C eta PRKCH Hs Inhibitor Inhibition 7.3 pKd
fms related tyrosine kinase 3 FLT3(D835H) Hs Inhibitor Inhibition 7.3 pKd
fms related tyrosine kinase 3 FLT3(ITD) Hs Inhibitor Inhibition 7.1 pKd
mitogen-activated protein kinase 15 ERK8 Hs Inhibitor Inhibition 7.1 pKd
Displaying the top 10 targets  View all targets in screen »