AGL 2043

Ligand id: 5918

Name: AGL 2043

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 71.84
Molecular weight 280.08
XLogP 3.15
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
platelet derived growth factor receptor alpha PDGFRα/PDGFRa Hs Inhibitor Inhibition 23.8 78.0 15.0
fms related tyrosine kinase 3 Flt3/FLT3 Hs Inhibitor Inhibition 27.5 15.0 1.0
KIT proto-oncogene receptor tyrosine kinase cKit/c-Kit Hs Inhibitor Inhibition 40.4 80.0 13.0
neurotrophic receptor tyrosine kinase 3 nd/TRKC Hs Inhibitor Inhibition 59.9
platelet derived growth factor receptor beta PDGFRβ/PDGFRb Hs Inhibitor Inhibition 63.3 97.0 46.0
colony stimulating factor 1 receptor Fms/FMS Hs Inhibitor Inhibition 63.5 52.0 8.0
neurotrophic receptor tyrosine kinase 2 TrkB/TRKB Hs Inhibitor Inhibition 64.7 69.0 45.0
YES proto-oncogene 1, Src family tyrosine kinase Tes/YES(YES1) Hs Inhibitor Inhibition 66.9 106.0 59.0
fibroblast growth factor receptor 3 FGFR3/FGFR3 Hs Inhibitor Inhibition 67.1 79.0 23.0
ret proto-oncogene Ret/RET Hs Inhibitor Inhibition 68.9 65.0 35.0
Displaying the top 10 targets  View all targets in screen »