Akt inhibitor X

Ligand id: 5922

Name: Akt inhibitor X

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 15.71
Molecular weight 344.17
XLogP 5.33
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
Pim-3 proto-oncogene, serine/threonine kinase Pim-3/PIM3 Hs Inhibitor Inhibition 37.8 92.0 47.0
Pim-1 proto-oncogene, serine/threonine kinase Pim-1/PIM1 Hs Inhibitor Inhibition 62.0 62.0 29.0
protein kinase N2 PRK2/PKN2(PRK2) Hs Inhibitor Inhibition 72.4 107.0 124.0
death associated protein kinase 1 DAPK1/DAPK1 Hs Inhibitor Inhibition 76.6 107.0 99.0
PAS domain containing serine/threonine kinase PASK/PASK Hs Inhibitor Inhibition 76.6 88.0 13.0
casein kinase 1 gamma 3 CK1γ3/CK1g3 Hs Inhibitor Inhibition 78.3 109.0 131.0
ribosomal protein S6 kinase A4 MSK2/MSK2(RPS6KA4) Hs Inhibitor Inhibition 80.8 111.0 116.0
protein kinase C alpha PKCα/PKCa Hs Inhibitor Inhibition 83.0 112.0 107.0
serine/threonine kinase 39 nd/STK39(STLK3) Hs Inhibitor Inhibition 83.5
mitogen-activated protein kinase 1 MAPK2/ERK2(MAPK1) Hs Inhibitor Inhibition 84.7 116.0 104.0
Displaying the top 10 targets  View all targets in screen »