aurora kinase inhibitor II

Ligand id: 5930

Name: aurora kinase inhibitor II

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 85.37
Molecular weight 400.15
XLogP 5.18
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1,3

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
aurora kinase B Aurora-B/Aurora B Hs Inhibitor Inhibition 2.0 0.0
tyrosine kinase non receptor 2 ACK1/ACK1 Hs Inhibitor Inhibition 13.0 1.0
aurora kinase A Aurora-A/Aurora A Hs Inhibitor Inhibition 18.0 12.0
BLK proto-oncogene, Src family tyrosine kinase Blk/BLK Hs Inhibitor Inhibition 20.0 2.0
LCK proto-oncogene, Src family tyrosine kinase Lck activated Hs Inhibitor Inhibition 30.0 9.0
LYN proto-oncogene, Src family tyrosine kinase Lyn/LYN Hs Inhibitor Inhibition 32.0 6.0
checkpoint kinase 2 CHK2/CHK2 Hs Inhibitor Inhibition 34.0 8.0
protein tyrosine kinase 6 BRK/BRK Hs Inhibitor Inhibition 35.0 10.0
erb-b2 receptor tyrosine kinase 4 ErbB4/ERBB4(HER4) Hs Inhibitor Inhibition 35.0 6.0
aurora kinase C Aurora-C/Aurora C Hs Inhibitor Inhibition 44.0 4.0
Displaying the top 10 targets  View all targets in screen »