aurora kinase/Cdk inhibitor

Ligand id: 5932

Name: aurora kinase/Cdk inhibitor

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 154.37
Molecular weight 394.07
XLogP 1.92
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
cyclin dependent kinase 5 CDK5-p35/CDK5-p35 Hs Inhibitor Inhibition 0.2 -1.0 0.0
tyrosine kinase 2 nd/TYK2 Hs Inhibitor Inhibition 0.9
cyclin dependent kinase 2 CDK2-cyclin A/CDK2-cyclin A Hs Inhibitor Inhibition 2.2 -1.0 1.0
cyclin dependent kinase 5 CDK5-p25/CDK5-p25 Hs Inhibitor Inhibition 2.5 0.0 0.0
NUAK family kinase 1 ARK5/ARK5(NUAK1) Hs Inhibitor Inhibition 3.3 4.0 7.0
Janus kinase 1 nd/JAK1 Hs Inhibitor Inhibition 5.2
cyclin dependent kinase 1 CDK1-cyclin B/CDK1-cyclin B Hs Inhibitor Inhibition 5.7 1.0 0.0
cyclin dependent kinase 2 CDK2/cyclin E Hs Inhibitor Inhibition 7.1
Janus kinase 3 JAK3/JAK3 Hs Inhibitor Inhibition 8.5 7.0 1.0
TAO kinase 2 TAO2/TAOK2(TAO1) Hs Inhibitor Inhibition 8.9 6.0 2.0
Displaying the top 10 targets  View all targets in screen »