Bcr-abl inhibitor GNF-2

Ligand id: 5935

Name: Bcr-abl inhibitor GNF-2

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 90.13
Molecular weight 374.1
XLogP 4.54
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 2-3

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
PDZ binding kinase nd/PBK(TOPK) Hs Inhibitor Inhibition 72.2
protein kinase C alpha PKCα/PKCa Hs Inhibitor Inhibition 77.4 115.0 110.0
dual specificity tyrosine phosphorylation regulated kinase 2 DYRK2/DYRK2 Hs Inhibitor Inhibition 78.7 102.0 91.0
mitogen-activated protein kinase kinase kinase 2 nd/MEKK2 Hs Inhibitor Inhibition 79.5
cyclin dependent kinase 5 CDK5-p25/CDK5-p25 Hs Inhibitor Inhibition 80.1 93.0 65.0
beta adrenergic receptor kinase 2 nd/GRK3 Hs Inhibitor Inhibition 80.5
death associated protein kinase 1 DAPK1/DAPK1 Hs Inhibitor Inhibition 81.1 104.0 99.0
serine/threonine kinase 16 nd/STK16 Hs Inhibitor Inhibition 81.8
cyclin dependent kinase 9 CDK9-cyclin T1/CDK9-cyclin T1 Hs Inhibitor Inhibition 82.2 102.0 69.0
tyrosine kinase 2 nd/TYK2 Hs Inhibitor Inhibition 82.7
Displaying the top 10 targets  View all targets in screen »