Cdc2-like kinase inhibitor

Ligand id: 5942

Name: Cdc2-like kinase inhibitor

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 54.84
Molecular weight 249.08
XLogP 2.99
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1,3

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
Pim-1 proto-oncogene, serine/threonine kinase Pim-1/PIM1 Hs Inhibitor Inhibition 17.9 25.0 4.0
CDC like kinase 4 nd/CLK4 Hs Inhibitor Inhibition 18.5
dual specificity tyrosine phosphorylation regulated kinase 2 DYRK2/DYRK2 Hs Inhibitor Inhibition 19.5 5.0 -5.0
histone H3 associated protein kinase Haspin/Haspin Hs Inhibitor Inhibition 25.0 17.0 4.0
CDC like kinase 2 CLK2/CLK2 Hs Inhibitor Inhibition 25.9 20.0 6.0
muscle associated receptor tyrosine kinase MuSK/MUSK Hs Inhibitor Inhibition 28.4 82.0 75.0
dual specificity tyrosine phosphorylation regulated kinase 1A nd/DYRK1(DYRK1A) Hs Inhibitor Inhibition 28.9
dual specificity tyrosine phosphorylation regulated kinase 1B nd/DYRK1B Hs Inhibitor Inhibition 32.9
CDC like kinase 1 nd/CLK1 Hs Inhibitor Inhibition 41.8
Pim-3 proto-oncogene, serine/threonine kinase Pim-3/PIM3 Hs Inhibitor Inhibition 47.4 51.0 11.0
Displaying the top 10 targets  View all targets in screen »