Cdk1 inhibitor

Ligand id: 5944

Name: Cdk1 inhibitor

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 44.89
Molecular weight 294.06
XLogP 4.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1,3

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
protein kinase C alpha PKCα/PKCa Hs Inhibitor Inhibition 63.2 106.0 95.0
Protein kinase G (PKG) 2 nd/PKG2(PRKG2) Hs Inhibitor Inhibition 71.7
protein kinase C eta PKCη/PKCeta Hs Inhibitor Inhibition 73.6 89.0 80.0
mitogen-activated protein kinase kinase kinase kinase 4 nd/HGK(MAP4K4) Hs Inhibitor Inhibition 75.7
protein tyrosine kinase 6 BRK/BRK Hs Inhibitor Inhibition 76.9 97.0 54.0
SRC proto-oncogene, non-receptor tyrosine kinase cSrc/c-SRC Hs Inhibitor Inhibition 78.5 115.0 80.0
cyclin dependent kinase 2 CDK2/cyclin E Hs Inhibitor Inhibition 79.9
fms related tyrosine kinase 3 Flt3/FLT3 Hs Inhibitor Inhibition 80.5 88.0 55.0
ribosomal protein S6 kinase A2 Rsk3/RSK3 Hs Inhibitor Inhibition 81.1 91.0 44.0
serine/threonine kinase 24 MST3/MST3(STK24) Hs Inhibitor Inhibition 81.5 83.0 67.0
Displaying the top 10 targets  View all targets in screen »