Cdk4 inhibitor

Ligand id: 5950

Name: Cdk4 inhibitor

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 0
Topological polar surface area 77.75
Molecular weight 403
XLogP 3.38
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
Pim-3 proto-oncogene, serine/threonine kinase Pim-3/PIM3 Hs Inhibitor Inhibition 4.7 29.0 14.0
mitogen-activated protein kinase kinase kinase 9 MLK1/MLK19MAP3K90 Hs Inhibitor Inhibition 7.6 85.0 31.0
fms related tyrosine kinase 3 Flt3/FLT3 Hs Inhibitor Inhibition 8.2 41.0 27.0
Pim-1 proto-oncogene, serine/threonine kinase Pim-1/PIM1 Hs Inhibitor Inhibition 8.8 28.0 13.0
cyclin dependent kinase 6 CDK6-cyclin D3/CDK6-cyclin D1 Hs Inhibitor Inhibition 12.2 87.0 58.0
mitogen-activated protein kinase kinase kinase 11 nd/MLK3(MAP3K11) Hs Inhibitor Inhibition 14.0
NUAK family kinase 1 ARK5/ARK5(NUAK1) Hs Inhibitor Inhibition 14.3 52.0 45.0
Insulin-like growth factor I receptor IGF-1R/IGF1R Hs Inhibitor Inhibition 15.0 87.0 91.0
cyclin dependent kinase 4 nd/CDK4/cyclin D3 Hs Inhibitor Inhibition 21.1
BR serine/threonine kinase 1 BrSK1/BRSK1 Hs Inhibitor Inhibition 21.5 82.0 55.0
Displaying the top 10 targets  View all targets in screen »