Cdk4 inhibitor II

Ligand id: 5951

Name: Cdk4 inhibitor II

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 62.58
Molecular weight 271.07
XLogP 2.88
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
glycogen synthase kinase 3 beta GSK3β/GSK3b Hs Inhibitor Inhibition 61.3 118.0 94.0
Protein kinase G (PKG) 2 nd/PKG2(PRKG2) Hs Inhibitor Inhibition 62.2
fms related tyrosine kinase 3 Flt3/FLT3 Hs Inhibitor Inhibition 71.0 83.0 73.0
calcium/calmodulin dependent protein kinase I CaMKI/CAMK1a Hs Inhibitor Inhibition 75.2 96.0 77.0
protein kinase C gamma PKCγ/PKCg Hs Inhibitor Inhibition 77.6 96.0 91.0
cyclin dependent kinase 2 CDK2/cyclin E Hs Inhibitor Inhibition 77.9
KIT proto-oncogene receptor tyrosine kinase cKit/c-Kit Hs Inhibitor Inhibition 78.6 93.0 93.0
serine/threonine kinase 24 MST3/MST3(STK24) Hs Inhibitor Inhibition 78.9 80.0 85.0
STE20 like kinase nd/SLK(STK2) Hs Inhibitor Inhibition 80.2
CDC like kinase 2 CLK2/CLK2 Hs Inhibitor Inhibition 81.2 99.0 74.0
Displaying the top 10 targets  View all targets in screen »