Cdk4 inhibitor III

Ligand id: 5952

Name: Cdk4 inhibitor III

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 87.3
Molecular weight 284.06
XLogP 3.62
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
Protein kinase G (PKG) 2 nd/PKG2(PRKG2) Hs Inhibitor Inhibition 60.8
cyclin dependent kinase 5 CDK5-p25/CDK5-p25 Hs Inhibitor Inhibition 61.9 102.0 97.0
cyclin dependent kinase 1 CDK1-cyclin B/CDK1-cyclin B Hs Inhibitor Inhibition 69.7 101.0 106.0
fms related tyrosine kinase 3 Flt3/FLT3 Hs Inhibitor Inhibition 72.5 85.0 81.0
cyclin dependent kinase 2 CDK2/cyclin E Hs Inhibitor Inhibition 72.9
ribosomal protein S6 kinase A6 Rsk4/RSK4 Hs Inhibitor Inhibition 73.4 72.0 111.0
KIT proto-oncogene receptor tyrosine kinase cKit/c-Kit Hs Inhibitor Inhibition 74.7 101.0 107.0
cyclin dependent kinase 1 nd/CDK1-cyclin A Hs Inhibitor Inhibition 75.9
dual serine/threonine and tyrosine protein kinase nd/RIPK5 Hs Inhibitor Inhibition 76.1
NIMA related kinase 1 nd/NEK1 Hs Inhibitor Inhibition 76.5
Displaying the top 10 targets  View all targets in screen »