DMBI

Ligand id: 5958

Name: DMBI

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 32.34
Molecular weight 264.13
XLogP 4.28
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
fms related tyrosine kinase 3 Flt3/FLT3 Hs Inhibitor Inhibition 15.3 4.0 1.0
neurotrophic receptor tyrosine kinase 3 nd/TRKC Hs Inhibitor Inhibition 36.3
KIT proto-oncogene receptor tyrosine kinase cKit/c-Kit Hs Inhibitor Inhibition 45.6 24.0 4.0
neurotrophic receptor tyrosine kinase 2 TrkB/TRKB Hs Inhibitor Inhibition 54.8 46.0 5.0
casein kinase 1 epsilon nd/CK1epsilon Hs Inhibitor Inhibition 57.2
aurora kinase B Aurora-B/Aurora B Hs Inhibitor Inhibition 61.4 13.0 4.0
mitogen-activated protein kinase kinase kinase 14 nd/NIK(MAP3K14) Hs Inhibitor Inhibition 67.7
casein kinase 1 delta CK1δ/CK1d Hs Inhibitor Inhibition 69.0 56.0 21.0
mitogen-activated protein kinase kinase kinase kinase 4 nd/HGK(MAP4K4) Hs Inhibitor Inhibition 74.5
colony stimulating factor 1 receptor Fms/FMS Hs Inhibitor Inhibition 77.5 8.0 2.0
Displaying the top 10 targets  View all targets in screen »