DNA-PK inhibitor V

Ligand id: 5961

Name: DNA-PK inhibitor V

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 49.77
Molecular weight 283.12
XLogP 3.71
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1,3

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
protein kinase C eta PKCη/PKCeta Hs Inhibitor Inhibition 70.0 116.0 83.0
mitogen-activated protein kinase kinase kinase 14 nd/NIK(MAP3K14) Hs Inhibitor Inhibition 75.1
mitogen-activated protein kinase 10 JNK3/JNK3 Hs Inhibitor Inhibition 75.3 83.0 53.0
LIM domain kinase 1 LIMK1/LIMK1 Hs Inhibitor Inhibition 83.9 105.0 80.0
protein kinase C alpha PKCα/PKCa Hs Inhibitor Inhibition 84.2 102.0 103.0
protein kinase C zeta PKCζ/PKCzeta Hs Inhibitor Inhibition 85.0 97.0 104.0
dual serine/threonine and tyrosine protein kinase nd/RIPK5 Hs Inhibitor Inhibition 86.2
mitogen-activated protein kinase kinase kinase kinase 4 nd/HGK(MAP4K4) Hs Inhibitor Inhibition 86.4
Protein kinase G (PKG) 1 PKG1β/PKG1b Hs Inhibitor Inhibition 86.8 93.0 80.0
serine/threonine kinase 24 MST3/MST3(STK24) Hs Inhibitor Inhibition 89.0 86.0 68.0
Displaying the top 10 targets  View all targets in screen »