ERK inhibitor II

Ligand id: 5966

Name: ERK inhibitor II

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 97.78
Molecular weight 327.12
XLogP 4.28
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
protein kinase C delta PKCδ/PKCd Hs Inhibitor Inhibition 31.2 22.0 4.0
mitogen-activated protein kinase 9 JNK2α2/JNK2 Hs Inhibitor Inhibition 48.4 55.0 9.0
mitogen-activated protein kinase kinase kinase kinase 5 nd/KHS(MAP4K5) Hs Inhibitor Inhibition 50.3
protein kinase D2 PKD2/PKD2(PRKD2) Hs Inhibitor Inhibition 54.1 96.0 49.0
ABL proto-oncogene 2, non-receptor tyrosine kinase Arg/ABL2(ARG) Hs Inhibitor Inhibition 57.5 66.0 18.0
protein kinase D3 nd/PKCnu(PRKD3) Hs Inhibitor Inhibition 58.9
mitogen-activated protein kinase kinase kinase kinase 4 nd/HGK(MAP4K4) Hs Inhibitor Inhibition 62.0
casein kinase 1 delta CK1δ/CK1d Hs Inhibitor Inhibition 63.2 60.0 17.0
fms related tyrosine kinase 3 Flt3/FLT3 Hs Inhibitor Inhibition 63.5 72.0 22.0
mitogen-activated protein kinase 3 MAPK1/ERK1 Hs Inhibitor Inhibition 65.8 21.0 3.0
Displaying the top 10 targets  View all targets in screen »