NPY-(2-36)

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Ligands
NPY-(2-36)

GtoPdb Ligand ID: 1549

Synonyms: neuropeptide Y (2-36)

Compound class: Peptide or derivative

Comment: Synthetic fragment of NPY. N.B. the amino acid sequence of NPY is common across human and rodent species

View interactive charts of activity data across species

2D Structure

SMILES / InChI / InChIKey

Canonical SMILES	NCCCCC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)O)Cc1ccc(cc1)O)CCCN=C(N)N)CCC(=O)N)CCCN=C(N)N)C(O)C)C(CC)C)CC(C)C)CC(=O)N)C(CC)C)Cc1ccc(cc1)O)Cc1nc[nH]c1)CCCN=C(N)N)CC(C)C)C)CO)Cc1ccc(cc1)O)Cc1ccc(cc1)O)CCCN=C(N)N)C)CCSC)CC(=O)O)CCC(=O)O)C)C)CC(=O)O)CCC(=O)O)CC(=O)N)CC(=O)O)NC(=O)C(NC(=O)C1CCCN1)CO
Isomeric SMILES	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC
InChI	InChI=1S/C180H275N53O56S/c1-15-88(7)140(170(282)223-120(76-132(183)242)160(272)215-115(70-87(5)6)163(275)229-141(89(8)16-2)171(283)230-142(94(13)236)172(284)212-108(32-23-64-198-180(191)192)148(260)210-110(52-55-131(182)241)153(265)208-107(31-22-63-197-179(189)190)151(263)225-125(176(288)289)74-98-42-50-103(240)51-43-98)228-164(276)118(73-97-40-48-102(239)49-41-97)218-159(271)119(75-99-81-193-85-200-99)219-150(262)106(30-21-62-196-178(187)188)209-156(268)114(69-86(3)4)214-145(257)91(10)202-165(277)126(83-234)227-158(270)117(72-96-38-46-101(238)47-39-96)217-157(269)116(71-95-36-44-100(237)45-37-95)216-149(261)105(29-20-61-195-177(185)186)206-143(255)90(9)201-147(259)112(58-68-290-14)211-161(273)122(79-138(251)252)221-154(266)111(54-57-136(247)248)207-144(256)92(11)203-168(280)129-34-25-65-231(129)173(285)93(12)204-155(267)121(78-137(249)250)220-152(264)109(53-56-135(245)246)205-134(244)82-199-167(279)128-33-24-66-232(128)175(287)124(77-133(184)243)224-162(274)123(80-139(253)254)222-169(281)130-35-26-67-233(130)174(286)113(27-17-18-59-181)213-166(278)127(84-235)226-146(258)104-28-19-60-194-104/h36-51,81,85-94,104-130,140-142,194,234-240H,15-35,52-80,82-84,181H2,1-14H3,(H2,182,241)(H2,183,242)(H2,184,243)(H,193,200)(H,199,279)(H,201,259)(H,202,277)(H,203,280)(H,204,267)(H,205,244)(H,206,255)(H,207,256)(H,208,265)(H,209,268)(H,210,260)(H,211,273)(H,212,284)(H,213,278)(H,214,257)(H,215,272)(H,216,261)(H,217,269)(H,218,271)(H,219,262)(H,220,264)(H,221,266)(H,222,281)(H,223,282)(H,224,274)(H,225,263)(H,226,258)(H,227,270)(H,228,276)(H,229,275)(H,230,283)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,288,289)(H4,185,186,195)(H4,187,188,196)(H4,189,190,197)(H4,191,192,198)/t88-,89-,90-,91-,92-,93-,94+,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,140-,141-,142-/m0/s1
InChI Key	KUMVUFICIDUBDZ-ZVYVYBDNSA-N

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Other Similar Sequences
neuropeptide Y {Sp: Human, Mouse, Rat}	Targets PrRP receptor; Y₁ receptor; Y₂ receptor; Y₄ receptor; Y₅ receptor
NPY {Sp: Pig}	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor
NPY-(13-36) (pig)	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor; Y₅ receptor
NPY-(2-36) (pig)	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor
NPY-(3-36) (pig)	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor; Y₅ receptor
peptide YY {Sp: Human}	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor; Y₅ receptor
peptide YY {Sp: Mouse, Rat, Pig}	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor; Y₅ receptor
PYY-(13-36) (mouse, rat, pig)	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor; Y₅ receptor
PYY-(3-36) {Sp: Human}	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor
[¹²⁵I]NPY (human, mouse, rat)	Targets Y₁ receptor; Y₂ receptor
[¹²⁵I]PYY (pig)	Targets Y₁ receptor; Y₄ receptor
[³H]NPY (human, mouse, rat)	Targets Y₁ receptor
[Ala³¹,Aib³²]NPY (pig)	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor; Y₅ receptor
[Leu³¹,Pro³⁴]NPY (pig)	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor; Y₅ receptor
[Leu³¹,Pro³⁴]PYY (pig)	Targets Y₁ receptor; Y₄ receptor
[Leu³¹,Pro³⁴]PYY (human)	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor; Y₅ receptor
N-α-Ac-PYY-(22-36) (rat)	Targets Y₂ receptor
N-α-Ac-PYY-(25-36) (rat)	Targets Y₂ receptor
C2-NPY (pig)	Targets Y₂ receptor
NPY-(13-36) (human)	Targets Y₂ receptor
NPY-(16-36) (pig)	Targets Y₂ receptor
NPY-(20-36) (pig)	Targets Y₂ receptor
NPY-(22-36) (pig)	Targets Y₂ receptor
NPY-(26-36) (pig)	Targets Y₂ receptor
PYY-(3-36) (pig)	Targets Y₂ receptor
[D-Trp³²]NPY	Targets Y₂ receptor; Y₅ receptor
[Leu³¹,Pro³⁴]NPY	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor
[Pro³⁴]PYY (human)	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor
PYY-(3-36) {Sp: Mouse, Rat}	Targets Y₄ receptor; Y₅ receptor
NPY-(18-36) (human, pig)	Targets PrRP receptor; Y₅ receptor
[Ala³¹,Aib³²]NPY	Targets Y₅ receptor
neuropeptide Y-(3-36) {Sp: Human, Mouse, Rat}	Targets Y₂ receptor
[¹²⁵I][Leu³¹,Pro³⁴]NPY	Targets Y₁ receptor
[¹²⁵I]PYY-(3-36) (human)	Targets Y₂ receptor
[Pro³⁴]NPY	Targets Y₁ receptor
NPY-(13-36)