BPS/IUPHAR Guide to Pharmacology | Ligand page

Ligand Id: 2349
Ligand name	L-(cis)-diltiazem

2D Structure

Calculated Physico-chemical Properties
Hydrogen bond acceptors	5
Hydrogen bond donors	0
Rotatable bonds	7
Topological polar surface area	84.38
Molecular weight	414.16
XLogP	3.64
No. Lipinski's rules broken	0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands Radio analogues

Similar Ligands

triflupromazine

GRAC targets

Maxi Cl^-

chlorpromazine

GRAC targets

Maxi Cl^-; TRPC5

IUPHAR-DB targets

α_2A-adrenoceptor; α_2B-adrenoceptor; α_2C-adrenoceptor; 5-HT_2A receptor; 5-HT_2C receptor; 5-HT₆ receptor; 5-HT₇ receptor; D₂ receptor; D₃ receptor; D₄ receptor; H₁ receptor

trifluoperazine

IUPHAR-DB targets

5-HT_2A receptor; 5-HT_2C receptor; H₁ receptor

fluphenazine

IUPHAR-DB targets

5-HT_2A receptor; 5-HT₆ receptor; 5-HT₇ receptor; D₁ receptor; D₅ receptor; H₁ receptor

perphenazine

IUPHAR-DB targets

5-HT_2A receptor; 5-HT_2C receptor; 5-HT₆ receptor; 5-HT₇ receptor; H₁ receptor

imipramine

IUPHAR-DB targets

K_v10.1; K_ir3.2; K_ir3.4; M₂ receptor

cis flupentixol

IUPHAR-DB targets

D₁ receptor; D₂ receptor; D₃ receptor; D₅ receptor

trans flupenthixol

IUPHAR-DB targets

D₂ receptor; D₃ receptor

cyamemazine

IUPHAR-DB targets

5-HT_1A receptor; 5-HT_2A receptor; 5-HT_2C receptor; 5-HT₇ receptor

clomipramine

IUPHAR-DB targets

K_ir3.2; K_ir3.4

zotepine

IUPHAR-DB targets

5-HT_1A receptor; 5-HT_1B receptor; 5-HT_1D receptor; 5-HT_2A receptor; 5-HT_2C receptor; 5-HT₆ receptor; 5-HT₇ receptor; 5-ht_1e receptor; H₁ receptor

diltiazem