Ligand Id: 3312
Ligand name L-leucine

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 63.32
Molecular weight 131.09
XLogP -1.39
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands

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Similar Ligands
[3H]AP4
IUPHAR-DB targets
mGlu4 receptor; mGlu8 receptor
L-AP4
GRAC targets
mGlu4 receptor; mGlu7 receptor; mGlu8 receptor
IUPHAR-DB targets
mGlu4 receptor; mGlu6 receptor; mGlu7 receptor; mGlu8 receptor
D-AP4
IUPHAR-DB targets
mGlu8 receptor
d-AP5
GRAC targets
GluN2A; GluN2B; GluN2C; GluN2D
[14C]glutamine
GRAC targets
SNAT3
L-glutamine
GRAC targets
Alanine/serine/cysteine transporter 2; B0AT3; NTT4; SNAT1; SNAT2; SNAT3; SNAT4; SNAT5; SNAT7
IUPHAR-DB targets
Alanine/serine/cysteine transporter 2; B0AT3; GPRC6 receptor; NTT4; SNAT1; SNAT2; SNAT3; SNAT4; SNAT5
[3H]glutamine
GRAC targets
SNAT3
meso-DAP
GRAC targets
NLRC1
L-homocysteine
GRAC targets
Cystathionine β-synthase
L-glutamic acid
GRAC targets
Alanine/serine/cysteine transporter 2; Citrin; Excitatory amino acid transporter 1; Excitatory amino acid transporter 3; Excitatory amino acid transporter 5; Glutamic acid decarboxylase 1; Glutamic acid decarboxylase 2; Mitochondrial glutamate carrier 1; Mitochondrial glutamate carrier 2; SLC26A7; SLC26A9; SNAT3; Sialin; Vesicular glutamate transporter 1; Vesicular glutamate transporter 2... click on ligand to see complete list
IUPHAR-DB targets
Alanine/serine/cysteine transporter 2; CaS receptor; SLC26A7; SLC26A9; SNAT3; Vesicular glutamate transporter 1; Vesicular glutamate transporter 2; mGlu1 receptor; mGlu2 receptor; mGlu3 receptor; mGlu4 receptor; mGlu5 receptor; mGlu6 receptor; mGlu7 receptor; mGlu8 receptor... click on ligand to see complete list
D-glutamic acid
GRAC targets
Vesicular glutamate transporter 1; Vesicular glutamate transporter 2; Vesicular glutamate transporter 3
IUPHAR-DB targets
Vesicular glutamate transporter 1; Vesicular glutamate transporter 2; Vesicular glutamate transporter 3
D-ornithine
GRAC targets
Mitochondrial ornithine transporter 2
D-lysine
GRAC targets
Mitochondrial ornithine transporter 2
L-lysine
GRAC targets
Cationic amino acid transporter 3; High affinity cationic amino acid transporter 1; Low affinity cationic amino acid transporter 2; Mitochondrial ornithine transporter 1 ; Mitochondrial ornithine transporter 2; SNAT4
IUPHAR-DB targets
GPRC6 receptor; SNAT4
L-ornithine
GRAC targets
Cationic amino acid transporter 3; High affinity cationic amino acid transporter 1; Low affinity cationic amino acid transporter 2; Mitochondrial ornithine transporter 1 ; Mitochondrial ornithine transporter 2; Ornithine decarboxylase
IUPHAR-DB targets
GPRC6 receptor
L-SOP
GRAC targets
mGlu4 receptor; mGlu7 receptor; mGlu8 receptor
IUPHAR-DB targets
mGlu1 receptor; mGlu2 receptor; mGlu3 receptor; mGlu4 receptor; mGlu5 receptor; mGlu6 receptor; mGlu7 receptor; mGlu8 receptor
hypoglaucin A
IUPHAR-DB targets
CXCR3
D-arginine
GRAC targets
Mitochondrial ornithine transporter 2
L-arginine
GRAC targets
Cationic amino acid transporter 3; High affinity cationic amino acid transporter 1; L-Arginine decarboxylase ; Low affinity cationic amino acid transporter 2; Mitochondrial ornithine transporter 1 ; Mitochondrial ornithine transporter 2; SNAT4
IUPHAR-DB targets
GPRC6 receptor; SNAT4
CGP37849
GRAC targets
GluN2A; GluN2B; GluN2C; GluN2D
L-methionine
GRAC targets
ATB0,+; Alanine/serine/cysteine transporter 2; B0AT1; B0AT2; B0AT3; L-type amino acid transporter 3; L-type amino acid transporter 4; NTT4; SNAT1; SNAT2
IUPHAR-DB targets
ATB0,+; Alanine/serine/cysteine transporter 2; B0AT1; B0AT2; B0AT3; NTT4; SNAT1; SNAT2
D-serine
GRAC targets
GluN1; GluN2A; GluN2B; GluN2C; GluN2D; Proton-coupled Amino acid Transporter 1
L-serine
GRAC targets
ATB0,+; Alanine/serine/cysteine transporter 1; Alanine/serine/cysteine transporter 2; B0AT1; B0AT2; CaS receptor; NTT4; SNAT1; SNAT2; SNAT4; SNAT5
IUPHAR-DB targets
ATB0,+; Alanine/serine/cysteine transporter 1; Alanine/serine/cysteine transporter 2; B0AT1; B0AT2; CaS receptor; GPRC6 receptor; NTT4; SNAT1; SNAT2; SNAT4; SNAT5
L-asparagine
GRAC targets
Alanine/serine/cysteine transporter 2; B0AT1; B0AT2; SNAT1; SNAT2; SNAT3; SNAT4; SNAT5; SNAT7
IUPHAR-DB targets
Alanine/serine/cysteine transporter 2; B0AT1; B0AT2; SNAT1; SNAT2; SNAT3; SNAT4; SNAT5
Nω-hydroxy-nor-L-arginine
[3H]D-aspartic acid
GRAC targets
Excitatory amino acid transporter 1; Excitatory amino acid transporter 2; Excitatory amino acid transporter 3; Excitatory amino acid transporter 4; Excitatory amino acid transporter 5
L-cysteine
GRAC targets
Alanine/serine/cysteine transporter 1; Alanine/serine/cysteine transporter 2; Cystathionine β-synthase; Cystathionine γ-lyase; Excitatory amino acid transporter 3; L-Cysteine:2-oxoglutarate aminotransferase; NTT4; SNAT1
IUPHAR-DB targets
Alanine/serine/cysteine transporter 1; Alanine/serine/cysteine transporter 2; NTT4; SNAT1
VPC44116
IUPHAR-DB targets
S1P1 receptor; S1P3 receptor; S1P5 receptor
[3H]L-aspartic acid
GRAC targets
Excitatory amino acid transporter 1; Excitatory amino acid transporter 2; Excitatory amino acid transporter 3; Excitatory amino acid transporter 4; Excitatory amino acid transporter 5
D-cysteine
GRAC targets
Proton-coupled Amino acid Transporter 1
L-aspartic acid
GRAC targets
Aralar; CaS receptor; Cation-chloride cotransporter 9; Citrin; Excitatory amino acid transporter 1; Excitatory amino acid transporter 2; Excitatory amino acid transporter 3; Excitatory amino acid transporter 4; Excitatory amino acid transporter 5; Glutamic acid decarboxylase 1; Glutamic acid decarboxylase 2; Sialin
IUPHAR-DB targets
CaS receptor; mGlu1 receptor; mGlu2 receptor; mGlu3 receptor; mGlu4 receptor; mGlu5 receptor; mGlu6 receptor; mGlu7 receptor; mGlu8 receptor
W146
GRAC targets
S1P1 receptor
IUPHAR-DB targets
S1P1 receptor
s-allylglycine
GRAC targets
Phosphatidylserine decarboxylase ; S-Adenosylmethionine decarboxylase
MAP4
GRAC targets
mGlu4 receptor; mGlu6 receptor
IUPHAR-DB targets
mGlu4 receptor; mGlu6 receptor; mGlu7 receptor; mGlu8 receptor
PMBA
GRAC targets
α1; α2
[3H]CGP39653
GRAC targets
GluN1; GluN2A; GluN2B; GluN2C; GluN2D
L-β-BA
GRAC targets
Excitatory amino acid transporter 3
L-valine
GRAC targets
ATB0,+; Alanine/serine/cysteine transporter 2; B0AT1; B0AT2; L-type amino acid transporter 3; L-type amino acid transporter 4; SNAT1
IUPHAR-DB targets
ATB0,+; Alanine/serine/cysteine transporter 2; B0AT1; B0AT2; SNAT1
L-isoleucine
GRAC targets
ATB0,+; B0AT1; B0AT2; L-type amino acid transporter 3; L-type amino acid transporter 4
IUPHAR-DB targets
ATB0,+; B0AT1; B0AT2
(R,S)-4-PPG
IUPHAR-DB targets
mGlu4 receptor; mGlu6 receptor; mGlu7 receptor; mGlu8 receptor
aminooxyacetic acid
GRAC targets
Cystathionine β-synthase
DL-threo-β-hydroxyaspartate
GRAC targets
Excitatory amino acid transporter 1; Excitatory amino acid transporter 2; Excitatory amino acid transporter 3; Excitatory amino acid transporter 4; Excitatory amino acid transporter 5
L-threonine
GRAC targets
Alanine/serine/cysteine transporter 1; Alanine/serine/cysteine transporter 2; B0AT1; B0AT2; SNAT1; SNAT2
IUPHAR-DB targets
Alanine/serine/cysteine transporter 1; Alanine/serine/cysteine transporter 2; B0AT1; B0AT2; SNAT1; SNAT2
pristanic acid
IUPHAR-DB targets
Peroxisome proliferator-activated receptor-α
PFA