Synonyms: (2R,6R)HNK
Compound class:
Synthetic organic
Comment: A recent (April 2016) report [1] shows that the metabolism of racemic ketamine to hydroxynorketamine (HNK) is essential for its antidepressant effects, and that these reside in this entry as the (2R,6R)-HNK enantiomer. In mice these actions are independent of NMDAR inhibition and lack ketamine-related side effects. The (flat) rendering of HNK is PubChem CID 133669. The (2S,6S)-HNK is represented as PubChem CID 71519584 but this showed a decreased antidepressant effect compared to (2R,6R)-HNK.
|
|
For advanced searching click here to open chemical structure editor
Similar Ligands |
No closely similar ligands found - try using advanced searching to find other ligands. |