AF12198   Click here for help

GtoPdb Ligand ID: 4861

Synonyms: AF 12198 | AF-12198
Immunopharmacology Ligand
Comment: Potent, selective human type I IL-1 receptor antagonist
Peptide Sequence Click here for help
FEWTPGWYQXYALPL
Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-Aze-Tyr-Ala-Leu-Pro-Leu-NH2
Chemical Modification
The C-terminal leucine residue is leucine amide, and the 11th residue is the unnatural amino acid 2-azetidine-1-carboxylic acid (2-carboxyazetidine, Aze). N-terminal pheneylalanine is acetylated