growth hormone 1   Click here for help

GtoPdb Ligand ID: 4943

Synonyms: NutropinAq® | Omnitrope® | Saizen® | somatotropin
Approved drug
growth hormone 1 is an approved drug (FDA (1976), EMA (2001))
Compound class: Endogenous peptide in human, mouse or rat
Comment: Human growth hormone 1 (somatropin) produced by recombinant technology is an approved drug with the INN somatropin. This has identical 191-amino acid sequence to the endogenous hormone.

Biosimilar drug: The EMA approved the biosimilar named Omnitrope (Sandoz GmbH) in 2006.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: growth hormone 1

Peptide Sequence Click here for help
FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISL
LLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNY
GLLYCFRKDMDKVETFLRIVQCRSVEGSCGF
Selected 3D Structures
PDB Id: 1a22
Image of ligand 3D structure from RCSB PDB
Post-translational Modification
Phosphorylated serine at positions 106 and 150; deamidation of glutamine at position 137 and asparagine at position 152 by deterioration; disulphide bond formation between cysteine residues at positions 53 and 165, and 182 and 189