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Synonyms: N(4) (0-1),Asp0,Tyr3-octreotate
Compound class:
Peptide or derivative
Comment: Demotate 2 can be radiolabelled with 99mTechnetium, a metastable nuclear isomer of Technetium-99 and is widely used in diagnostic nuclear medicine.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
Peptide Sequence  |
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| DFYWKTCT | |
| Asp-Phe-Tyr-Trp-Lys-Thr-Cys-Thr-OH | |
| Chemical Modification | |
| To synthesise demotate 2, N,N′,N″,N′″-tetra-(tert-butoxycarbonyl)-6-(carboxy)-1,4,8,11 -tetraazaundecane was coupled at the N-terminus Asp of the octapeptide DFYWKTCT and the product cyclicised in the presence of DMSO and then purified [1]. | |
