Compound class:
Synthetic organic
Comment: cis-JB253 is described in [1]. The structure is based upon that of the diabetes sulfonylurea drug glimepiride. This compound is formed from trans-JB253 upon photoisomerization using blue light. This isomerization process is reversible. The molecule is active in the cis-state, increasing insulin production from pancreatic B-cells in vitro. It is postulated that this type of photoswitchable compound could in the future, allow better control of blood glucose in diabetic patients [1].
Note that the PubChem CID we link to does not specify the cis-trans state of the compound. |
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Molecular structure representations generated using Open Babel