Synonyms: Dipeptide 9f [PMID 19175320] | GAP-134 | ZP-123
Compound class:
Peptide or derivative
Comment: Rotigaptide is a hexapeptide developed originally by Wyeth, as an anti-arrhythmic agent. It promotes electrical coupling between ventricular myocytes by increasing gap junction conductance [1]. A recent study showed reduction in myocardial infarction size in a porcine model and protection from IRI-related endothelial dysfunction in man. Rotigaptide may thus have therapeutic potential in the treatment of myocardial infarction [2].
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Peptide Sequence | |
Ac-D-Tyr-D-Pro-D-aHyp-Gly-D-Ala-Gly-NH2 |
Download 2D Structure | |
Canonical SMILES | Download |
Isomeric SMILES | Download |
InChI standard identifier | Download |
InChI standard key | Download |
Molecular structure representations generated using Open Babel