|
Compound class:
Peptide or derivative
Comment: Apelin mimetic peptide agonist with reduced conformational flexibility, adopts a lactam constrained curved structure [1].
|
Peptide Sequence  |
|
| KFRRQRPXXQHKKXXPX | |
| Lys-Phe-Arg-Arg-Gln-Arg-Pro-hArg-Cha-Glu-His-Lys-Lys-Oic-Nle-Pro-4-Cl-Phe | |
| Chemical Modification | |
| hArg, Cha, Oic, Nle and 4-Cl-Phe are unnatural amino acid counterparts. There is a lactam ring between Glu8 and Lys13 [1]. | |
