(-)-pentazocine

Ligand id: 1606

Name: (-)-pentazocine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 23.47
Molecular weight 285.21
XLogP 4.09
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1967))
International Nonproprietary Names
INN number INN
1674 pentazocine
Synonyms
pentazocine | WIN-20228
Database Links
BindingDB Ligand 50001028
CAS Registry No. 359-83-1 (source: Scifinder)
ChEMBL Ligand CHEMBL560
DrugBank Ligand DB00652
GtoPdb PubChem SID 135650806
PubChem CID 441278
Search Google for chemical match using the InChIKey VOKSWYLNZZRQPF-GDIGMMSISA-N
Search Google for chemicals with the same backbone VOKSWYLNZZRQPF
Search PubMed clinical trials pentazocine
Search PubMed titles pentazocine
Search PubMed titles/abstracts pentazocine
Search UniChem for chemical match using the InChIKey VOKSWYLNZZRQPF-GDIGMMSISA-N
Search UniChem for chemicals with the same backbone VOKSWYLNZZRQPF
Wikipedia Pentazocine
Comments
(-)-pentazocine is one of the two enantiomers in the approved drug pentazocine. (-)-pentazocine is a κ-opioid receptor agonist, while (+)-pentazocine exhibits ten-fold greater affinity for the σ receptor. Pentazocine is a mixed agonist-antagonist opioid pain medication. It is postulated that pentazocine behaves as an agonist at the κ and σ opioid receptors and has weak antagonistic action at the μ receptor.