asenapine

Ligand id: 22

Name: asenapine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: asenapine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 12.47
Molecular weight 285.09
XLogP 4.27
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2009), EMA (2010))
IUPAC Name
(2S,6S)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.0^{2,6}.0^{7,12}]octadeca-1(18),7,9,11,14,16-hexaene
International Nonproprietary Names
INN number INN
8278 asenapine
Synonyms
ORG-5222 | Saphris® | Sycrest®
Database Links
CAS Registry No. 65576-45-6 (source: Scifinder)
ChEBI CHEBI:71257
ChEMBL Ligand CHEMBL504548
PubChem CID 163091
Search Google for chemical match using the InChIKey VSWBSWWIRNCQIJ-HUUCEWRRSA-N
Search Google for chemicals with the same backbone VSWBSWWIRNCQIJ
Search PubMed clinical trials asenapine
Search PubMed titles asenapine
Search PubMed titles/abstracts asenapine
Search UniChem for chemical match using the InChIKey VSWBSWWIRNCQIJ-HUUCEWRRSA-N
Search UniChem for chemicals with the same backbone VSWBSWWIRNCQIJ
Wikipedia Asenapine
Comments
Asenapine is an atypical antipsychotic. The drug is an enantiomeric mixture, and we show one enantioner here. Alternative enantiomers include CHEMBL1201756.
Marketed formulations may contain asenapine maleate (PubChem CID 6917875).