colchicine

Ligand id: 2367

Name: colchicine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 83.09
Molecular weight 399.17
XLogP 1.73
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2009))
IUPAC Name
N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]acetamide
Synonyms
Colcrys®
Database Links
BindingDB Ligand 50014846
BitterDB Ligand 92
CAS Registry No. 64-86-8 (source: DrugBank)
ChEBI CHEBI:27882
ChEMBL Ligand CHEMBL107
DrugBank Ligand DB01394
GtoPdb PubChem SID 135650118
PubChem CID 6167
RCSB PDB Ligand LOC
Search Google for chemical match using the InChIKey IAKHMKGGTNLKSZ-INIZCTEOSA-N
Search Google for chemicals with the same backbone IAKHMKGGTNLKSZ
Search UniChem for chemical match using the InChIKey IAKHMKGGTNLKSZ-INIZCTEOSA-N
Search UniChem for chemicals with the same backbone IAKHMKGGTNLKSZ
Wikipedia Colchicine
Comments
Approved for use in combination with probenecid as early as 1961. US FDA formal approval was only granted for the single ingredient drug in 2009, although it had been marketed prior to this date without formal approval.