nicardipine

Ligand id: 2559

Name: nicardipine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: nicardipine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 11
Topological polar surface area 111.01
Molecular weight 479.21
XLogP 6.67
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1988))
IUPAC Name
O5-methyl O3-[2-(methyl-(phenylmethyl)amino)ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
International Nonproprietary Names
INN number INN
4745 nicardipine
Synonyms
(R,S)-nicardipine | Cardene®
Database Links
BindingDB Ligand 50017085
CAS Registry No. 55985-32-5 (source: Scifinder)
ChEBI CHEBI:507549
ChEMBL Ligand CHEMBL1484
DrugBank Ligand DB00622
PubChem CID 4474
Search Google for chemical match using the InChIKey ZBBHBTPTTSWHBA-UHFFFAOYSA-N
Search Google for chemicals with the same backbone ZBBHBTPTTSWHBA
Search PubMed clinical trials nicardipine
Search PubMed titles nicardipine
Search PubMed titles/abstracts nicardipine
Search UniChem for chemical match using the InChIKey ZBBHBTPTTSWHBA-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone ZBBHBTPTTSWHBA
Wikipedia Nicardipine
Comments
One of the dihydropyridine class of drugs.