retigabine

Ligand id: 2601

Name: retigabine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 76.38
Molecular weight 303.14
XLogP 3.2
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA and EMA (2011))
IUPAC Name
ethyl N-[2-amino-4-[(4-fluorophenyl)methylamino]phenyl]carbamate
International Nonproprietary Names
INN number INN
7545 retigabine
Synonyms
AWD-21360 | D-23129 | ezogabine | Potiga® | Trobalt® | WAY-143841
Database Links
BindingDB Ligand 50143558
CAS Registry No. 150812-12-7 (source: Scifinder)
ChEBI CHEBI:161945
ChEMBL Ligand CHEMBL41355
DrugBank Ligand DB04953
PubChem CID 121892
Search Google for chemical match using the InChIKey PCOBBVZJEWWZFR-UHFFFAOYSA-N
Search Google for chemicals with the same backbone PCOBBVZJEWWZFR
Search PubMed clinical trials retigabine
Search PubMed titles retigabine
Search PubMed titles/abstracts retigabine
Search UniChem for chemical match using the InChIKey PCOBBVZJEWWZFR-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone PCOBBVZJEWWZFR
Wikipedia Retigabine
Comments
Retigabine is unique among antiepileptic drugs in that it functions by activating selected voltage-gated potassium channels in the brain (i.e. Kv7 family channels) [2] [3].