cortisol

Ligand id: 2868

Name: cortisol

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: cortisol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 94.83
Molecular weight 362.21
XLogP 0.55
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Metabolite or derivative
Approved drug? Yes (FDA (1953, prior history unavailable))
IUPAC Name
(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
International Nonproprietary Names
INN number INN
38 hydrocortisone
Synonyms
Acticort® | Plenadren®
Database Links
BindingDB Ligand 22476
BitterDB Ligand 129
CAS Registry No. 50-23-7 (source: Scifinder)
ChEBI CHEBI:17650
ChEMBL Ligand CHEMBL389621
DrugBank Ligand DB00741
GtoPdb PubChem SID 53801089
NURSA Ligand 10.1621/WQEMKA13C7
PubChem CID 5754
RCSB PDB Ligand HCY
Search Google for chemical match using the InChIKey JYGXADMDTFJGBT-VWUMJDOOSA-N
Search Google for chemicals with the same backbone JYGXADMDTFJGBT
Search PubMed clinical trials hydrocortisone
Search PubMed titles hydrocortisone
Search PubMed titles/abstracts hydrocortisone
Search UniChem for chemical match using the InChIKey JYGXADMDTFJGBT-VWUMJDOOSA-N
Search UniChem for chemicals with the same backbone JYGXADMDTFJGBT
SynPHARM 6573 (in complex with Glucocorticoid receptor)
Wikipedia Cortisol
Comments
Cortisol is an endogenous adrenal glucocorticoid with immunosuppressant action. Approved as hydrocortisone. Hydrocortisone is a glucocorticoid receptor agonist.
Marketed formulations may contain hydrocortisone acetate (PubChem CID 5744).