ACTH

Ligand id: 3633

Name: ACTH

Species: Human

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: acth

Classification
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Neuropeptides
Approved drug? Yes (FDA (1950))
International Nonproprietary Names
INN number INN
1366 corticotropin
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
POMC proopiomelanocortin Human pro-opiomelanocortin ACTH, adrenocorticotropic hormone, adrenocorticotropin, alpha-melanocyte stimulating hormone, beta-endorphin, beta-lipotropin, beta-melanocyte stimulating hormone, CLIP, LPH, MSH, NPP, POC
Synonyms
Acthar® | adrenocorticotropic hormone (1-39) | corticotropin
Database Links
CAS Registry No. 12279-41-3 (Hs)
ChEMBL Ligand CHEMBL1201610
DrugBank Ligand DB01285
Ensembl Gene ENSG00000115138 (Hs)
Entrez Gene 5443 (Hs)
Human Protein Atlas ENSG00000115138 (Hs)
Search PubMed clinical trials corticotropin
Search PubMed titles corticotropin
Search PubMed titles/abstracts corticotropin
UniProtKB P01189 (Hs)
Wikipedia ACTH
Comments
This is an enodgenous peptide secreted by the pituitary gland, but is used as a drug with the approved name of corticotropin. Corticotropin is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress.