5-fluorouracil

Ligand id: 4789

Name: 5-fluorouracil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 0
Topological polar surface area 58.2
Molecular weight 130.02
XLogP -0.59
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1962))
Prodrug capecitabinefloxuridine
IUPAC Name
5-fluoro-1,2,3,4-tetrahydropyrimidine-2,4-dione
International Nonproprietary Names
INN number INN
1421 fluorouracil
Synonyms
Adrucil® | Carac®
Database Links
CAS Registry No. 51-21-8
ChEMBL Ligand CHEMBL185
DrugBank Ligand DB00544
PubChem CID 3385
RCSB PDB Ligand URF
Search Google for chemical match using the InChIKey GHASVSINZRGABV-UHFFFAOYSA-N
Search Google for chemicals with the same backbone GHASVSINZRGABV
Search PubMed clinical trials fluorouracil
Search PubMed titles fluorouracil
Search PubMed titles/abstracts fluorouracil
Search UniChem for chemical match using the InChIKey GHASVSINZRGABV-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone GHASVSINZRGABV
Wikipedia 5-fluorouracil
Comments
Fluoroacil is the active metabolite of the prodrugs capecitabine and floxuridine.