reboxetine

Ligand id: 4808

Name: reboxetine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 39.72
Molecular weight 313.17
XLogP 4.53
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes
IUPAC Name
(2S)-2-[(S)-2-ethoxyphenoxy(phenyl)methyl]morpholine
International Nonproprietary Names
INN number INN
5858 reboxetine
Synonyms
Edronax® | PNU-165442G
Database Links
CAS Registry No. 71620-89-8 (source: Scifinder)
ChEBI CHEBI:114263
ChEMBL Ligand CHEMBL180101
DrugBank Ligand DB00234
PubChem CID 65856
Search Google for chemical match using the InChIKey CBQGYUDMJHNJBX-OALUTQOASA-N
Search Google for chemicals with the same backbone CBQGYUDMJHNJBX
Search PubMed clinical trials reboxetine
Search PubMed titles reboxetine
Search PubMed titles/abstracts reboxetine
Search UniChem for chemical match using the InChIKey CBQGYUDMJHNJBX-OALUTQOASA-N
Search UniChem for chemicals with the same backbone CBQGYUDMJHNJBX
Wikipedia Reboxetine
Comments
Reboxetine is a norepinephrine reuptake inhibitor (NRI) antidepressant. It is ~20-fold selective for the norepinephrine transporter over the serotonin transporter, so at therapeutic doses some inhibition of serotonin uptake is observed.