silodosin

Ligand id: 493

Name: silodosin

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 14
Topological polar surface area 97.05
Molecular weight 495.23
XLogP 3.63
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2008), EMA (2010))
IUPAC Name
1-(3-hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,3-dihydroindole-7-carboxamide
International Nonproprietary Names
INN number INN
8043 silodosin
Synonyms
KMD-3213 | Rapaflo® | Silodyx®
Database Links
BindingDB Ligand 50160154
CAS Registry No. 160970-54-7 (source: Scifinder)
ChEMBL Ligand CHEMBL24778
DrugBank Ligand DB06207
GtoPdb PubChem SID 135650458
PubChem CID 5312125
Search Google for chemical match using the InChIKey PNCPYILNMDWPEY-QGZVFWFLSA-N
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Search PubMed clinical trials silodosin
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Search UniChem for chemical match using the InChIKey PNCPYILNMDWPEY-QGZVFWFLSA-N
Search UniChem for chemicals with the same backbone PNCPYILNMDWPEY
Wikipedia Silodosin
Comments
Silodosin an α1-adrenoceptor antagonist with selectivity for prostate adrenoceptors (mainly the α1A subtype).