CHIR-265

Ligand id: 5674

Name: CHIR-265

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 80.65
Molecular weight 518.13
XLogP 7.09
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-methyl-5-({2-[4-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl}oxy)-N-[4-(trifluoromethyl)phenyl]-1H-1,3-benzodiazol-2-amine
Synonyms
CHIR 265 | CHIR265 | RAF 265 | RAF-265 | RAF265
Database Links
CAS Registry No. 927880-90-8
ChEMBL Ligand CHEMBL558752
PubChem CID 11656518
RCSB PDB Ligand 55J
Search Google for chemical match using the InChIKey YABJJWZLRMPFSI-UHFFFAOYSA-N
Search Google for chemicals with the same backbone YABJJWZLRMPFSI
Search UniChem for chemical match using the InChIKey YABJJWZLRMPFSI-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone YABJJWZLRMPFSI
SynPHARM 81173 (in complex with B-Raf proto-oncogene, serine/threonine kinase)
Comments
CHIR-265 is an orally bioavailable inhibitor of RAF kinases, including the BRAF V600E mutant. It also inhibits phosphorylation of VEGFR2 [3] (link to this abstract at AACR Meeting Abstracts Online #4876).