GW-2580

Ligand id: 5685

Name: GW-2580

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 105.51
Molecular weight 366.17
XLogP 2.67
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
5-({3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl}methyl)pyrimidine-2,4-diamine
Synonyms
cFMS receptor tyrosine kinase inhibitor | GW2580 | GW632580X
Database Links
CAS Registry No. 870483-87-7
ChEMBL Ligand CHEMBL261849
GtoPdb PubChem SID 178102312
PubChem CID 11617559
RCSB PDB Ligand MUJ
Search Google for chemical match using the InChIKey MYQAUKPBNJWPIE-UHFFFAOYSA-N
Search Google for chemicals with the same backbone MYQAUKPBNJWPIE
Search UniChem for chemical match using the InChIKey MYQAUKPBNJWPIE-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone MYQAUKPBNJWPIE
SynPHARM 83183 (in complex with neurotrophic receptor tyrosine kinase 2)
Comments
GW-2580 is an inhibitor of the receptor tyrosine kinase, colony stimulating factor 1 receptor (CSF1R or FMS) [2]. CSF1R inhibitors are considered to have therapeutic potential for the prevention of osteolytic disease associated with bone metastasis and other bone diseases. GW-2580 has been assessed in preclinical investigations.