pazopanib

Ligand id: 5698

Name: pazopanib

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 127.41
Molecular weight 437.16
XLogP 2.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2009), EMA (2010))
IUPAC Name
5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide
International Nonproprietary Names
INN number INN
8681 pazopanib
Synonyms
GW 786034 | indazolylpyrimidine 13 [4] | Votrient®
Database Links
CAS Registry No. 444731-52-6
ChEMBL Ligand CHEMBL477772
GtoPdb PubChem SID 178102325
PubChem CID 10113978
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Wikipedia Pazopanib
Comments
Pazopanib is a Type-1 kinase inhibitor. Its discovery is reported in [5]. It targets multiple receptor tyrosine kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRβ, FGFR1, Kit and CSF1R).