sunitinib

Ligand id: 5713

Name: sunitinib

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 77.23
Molecular weight 398.21
XLogP 3.4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA and EMA (2006))
IUPAC Name
N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide
International Nonproprietary Names
INN number INN
8646 sunitinib
Synonyms
SU11248 | Sutent®
Database Links
CAS Registry No. 557795-19-4
ChEMBL Ligand CHEMBL535
DrugBank Ligand DB01268
GtoPdb PubChem SID 178102339
PubChem CID 5329102
RCSB PDB Ligand B49
Search Google for chemical match using the InChIKey WINHZLLDWRZWRT-ATVHPVEESA-N
Search Google for chemicals with the same backbone WINHZLLDWRZWRT
Search PubMed clinical trials sunitinib
Search PubMed titles sunitinib
Search PubMed titles/abstracts sunitinib
Search UniChem for chemical match using the InChIKey WINHZLLDWRZWRT-ATVHPVEESA-N
Search UniChem for chemicals with the same backbone WINHZLLDWRZWRT
SynPHARM 81287 (in complex with kinase insert domain receptor)
81286 (in complex with KIT proto-oncogene receptor tyrosine kinase)
81225 (in complex with KIT proto-oncogene receptor tyrosine kinase)
Wikipedia Sunitinib
Comments
Sunitinib is a Type-1 kinase inhibitor and was first approved by the US FDA and EMA in 2006.