vandetanib

Ligand id: 5717

Name: vandetanib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 59.51
Molecular weight 474.11
XLogP 4.17
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2011), EMA (2012))
IUPAC Name
N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
International Nonproprietary Names
INN number INN
8365 vandetanib
Synonyms
Caprelsa® | CH 331 | ZD 6474 | ZD-6474 | ZD6474
Database Links
CAS Registry No. 443913-73-3
ChEMBL Ligand CHEMBL24828
DrugBank Ligand DB05294
PubChem CID 3081361
RCSB PDB Ligand ZD6
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Wikipedia Vandetanib
Comments
Vandetanib is a Type-1 kinase inhibitor. It potently inhibits RET, VEGFR-2 and EGFR tyrosine kinase activity [2].