lorazepam

Ligand id: 5884

Name: lorazepam

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View more information in the IUPHAR Pharmacology Education Project: lorazepam

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 61.69
Molecular weight 320.01
XLogP 3.88
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1977))
IUPAC Name
7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
International Nonproprietary Names
INN number INN
2809 lorazepam
Synonyms
Ativan® | Orfidal®
Database Links
CAS Registry No. 846-49-1 (source: SciFinder)
ChEMBL Ligand CHEMBL580
DrugBank Ligand DB00186
GtoPdb PubChem SID 178102508
PubChem CID 3958
Search Google for chemical match using the InChIKey DIWRORZWFLOCLC-UHFFFAOYSA-N
Search Google for chemicals with the same backbone DIWRORZWFLOCLC
Search PubMed clinical trials lorazepam
Search PubMed titles lorazepam
Search PubMed titles/abstracts lorazepam
Search UniChem for chemical match using the InChIKey DIWRORZWFLOCLC-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone DIWRORZWFLOCLC
Wikipedia Lorazepam
Comments
Lorazepam is used for the short-term management of severe anxiety. where it is thought to have a high affinity for GABA receptors. In March of 2016 it has also been reported as a GPR68 surrogate allosteric ligand [1].