cabozantinib

Ligand id: 5887

Name: cabozantinib

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 98.78
Molecular weight 501.17
XLogP 5.79
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2012), EMA (2014))
IUPAC Name
N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
International Nonproprietary Names
INN number INN
9297 cabozantinib
Synonyms
BMS907351 | Cabometyx® | Cometriq® | XL-184 | XL184
Database Links
CAS Registry No. 849217-68-1 (source: SciFinder)
ChEBI CHEBI:72317
ChEMBL Ligand CHEMBL2105717
PubChem CID 25102847
Search Google for chemical match using the InChIKey ONIQOQHATWINJY-UHFFFAOYSA-N
Search Google for chemicals with the same backbone ONIQOQHATWINJY
Search PubMed clinical trials cabozantinib
Search PubMed titles cabozantinib
Search PubMed titles/abstracts cabozantinib
Search UniChem for chemical match using the InChIKey ONIQOQHATWINJY-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone ONIQOQHATWINJY
Wikipedia Cabozantinib
Comments
Cabozantinib is a Type-1, oral, small-molecule tyrosine kinase inhibitor.
Marketed formulations contain cabozantinib S-malate (PubChem CID 25102846).