EGFR/ErbB-2 inhibitor

Ligand id: 5964

Name: EGFR/ErbB-2 inhibitor

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 65.5
Molecular weight 387.16
XLogP 5.65
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
N-[4-(benzyloxy)phenyl]-6,7-dimethoxyquinazolin-4-amine
Synonyms
4557W
Database Links
CAS Registry No. 179248-61-4
ChEMBL Ligand CHEMBL563845
PubChem CID 9843206
Search Google for chemical match using the InChIKey DNOKYISWMVFYFA-UHFFFAOYSA-N
Search Google for chemicals with the same backbone DNOKYISWMVFYFA
Search UniChem for chemical match using the InChIKey DNOKYISWMVFYFA-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone DNOKYISWMVFYFA
Comments
This compound is a cell-permeable, potent, reversible, and ATP-competitive inhibitor of EGFR and ERBB2 [2].