ERK inhibitor II

Ligand id: 5966

Name: ERK inhibitor II

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 97.78
Molecular weight 327.12
XLogP 4.28
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
5-{2-phenylpyrazolo[1,5-a]pyridin-3-yl}-2H-pyrazolo[3,4-c]pyridazin-3-amine
Synonyms
FR-180204 | FR180204
Database Links
CAS Registry No. 865362-74-9
ChEMBL Ligand CHEMBL259551
DrugBank Ligand DB07794
PubChem CID 11493598
RCSB PDB Ligand FRZ
Search Google for chemical match using the InChIKey XVECMUKVOMUNLE-UHFFFAOYSA-N
Search Google for chemicals with the same backbone XVECMUKVOMUNLE
Search UniChem for chemical match using the InChIKey XVECMUKVOMUNLE-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone XVECMUKVOMUNLE
SynPHARM 80614 (in complex with mitogen-activated protein kinase 1)
Comments
FR180204 is a potent cell-permeable inhibitor of ERK1 and ERK2. It is much less effective against p38 MAPKα and does not inhibit a range of other serine/threonine or tyrosine kinases [3].