ramipril

Ligand id: 6339

Name: ramipril

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 95.94
Molecular weight 416.23
XLogP 4.92
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1991))
Is prodrug? Yes
Active form ramiprilat
IUPAC Name
(2S,3aS,6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[d]pyrrole-2-carboxylic acid
International Nonproprietary Names
INN number INN
5561 ramipril
Synonyms
Altace® | HOE-498 | Tritace®
Database Links
ChEBI CHEBI:8774
ChEMBL Ligand CHEMBL1168
DrugBank Ligand DB00178
PubChem CID 5362129
Search Google for chemical match using the InChIKey HDACQVRGBOVJII-JBDAPHQKSA-N
Search Google for chemicals with the same backbone HDACQVRGBOVJII
Search PubMed clinical trials ramipril
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Search UniChem for chemical match using the InChIKey HDACQVRGBOVJII-JBDAPHQKSA-N
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Wikipedia Ramipril
Comments
Pro-drug, transformed in the liver to its active metabolite (drug) ramiprilat