benazepril

Ligand id: 6374

Name: benazepril

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 95.94
Molecular weight 424.2
XLogP 6.28
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1991))
Is prodrug? Yes
Active form benazeprilat
IUPAC Name
2-[(3S)-3-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid
International Nonproprietary Names
INN number INN
6129 benazepril
Synonyms
CGS-14824A | Lotensin®
Database Links
CAS Registry No. 86541-75-5 (source: PubChem)
ChEBI CHEBI:3011
ChEMBL Ligand CHEMBL838
DrugBank Ligand DB00542
PubChem CID 5362124
Search Google for chemical match using the InChIKey XPCFTKFZXHTYIP-PMACEKPBSA-N
Search Google for chemicals with the same backbone XPCFTKFZXHTYIP
Search PubMed clinical trials benazepril
Search PubMed titles benazepril
Search PubMed titles/abstracts benazepril
Search UniChem for chemical match using the InChIKey XPCFTKFZXHTYIP-PMACEKPBSA-N
Search UniChem for chemicals with the same backbone XPCFTKFZXHTYIP
Wikipedia Benazepril
Comments
Benazepril (an ACE inhibitor) is administered as an ester is a prodrug, which is metabolized by the liver into its active form benazeprilat.