CTEP

Ligand id: 6409

Name: CTEP

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 39.94
Molecular weight 391.07
XLogP 6.4
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
2-chloro-4-[2-[2,5-dimethyl-1-[4-(trifluoromethoxy)phenyl]imidazol-4-yl]ethynyl]pyridine
Synonyms
compound 3 [PMID: 25565255]
Database Links
PubChem CID 11646823
Search Google for chemical match using the InChIKey GOHCTCOGYKAJLZ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone GOHCTCOGYKAJLZ
Search UniChem for chemical match using the InChIKey GOHCTCOGYKAJLZ-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone GOHCTCOGYKAJLZ
Wikipedia CTEP
Comments
CTEP is a negative allosteric modulator (NAM) of the glutamate metabotropic receptor 5 (mGlu5) GPCR [1-2]. Structurally, CTEP and basimglurant and are analogues. CTEP has a notably longer half-life in rodents (49 hours) than basimglurant (~10 hours), so is better suited for rodents studies requiring chronic exposure/treatment.