trandolapril

Ligand id: 6453

Name: trandolapril

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 95.94
Molecular weight 430.25
XLogP 5.49
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1996))
Is prodrug? Yes
Active form trandolaprilat
IUPAC Name
(2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
International Nonproprietary Names
INN number INN
5746 trandolapril
Synonyms
CI-907 | indolapril | Mavik® | RU-44570
Database Links
CAS Registry No. 87679-37-6 (source: PubChem)
ChEMBL Ligand CHEMBL1519
DrugBank Ligand DB00519
PubChem CID 5484727
Search Google for chemical match using the InChIKey VXFJYXUZANRPDJ-WTNASJBWSA-N
Search Google for chemicals with the same backbone VXFJYXUZANRPDJ
Search PubMed clinical trials trandolapril
Search PubMed titles trandolapril
Search PubMed titles/abstracts trandolapril
Search UniChem for chemical match using the InChIKey VXFJYXUZANRPDJ-WTNASJBWSA-N
Search UniChem for chemicals with the same backbone VXFJYXUZANRPDJ
Wikipedia Trandolapril
Comments
Metabolized to its biologically active diacid (drug) trandolaprilat in the liver.