spirapril

Ligand id: 6575

Name: spirapril

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 146.54
Molecular weight 466.16
XLogP 5
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1994))
Withdrawn drug? Yes
Is prodrug? Yes
Active form spiraprilat
IUPAC Name
(7S)-8-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-8-azaspiro[4.4]nonane-7-carboxylic acid
International Nonproprietary Names
INN number INN
6006 spirapril
Synonyms
Renormax® | SCH-33844
Database Links
CAS Registry No. 83647-97-6 (source: PubChem)
ChEMBL Ligand CHEMBL431
DrugBank Ligand DB01348
PubChem CID 5311447
Search Google for chemical match using the InChIKey HRWCVUIFMSZDJS-SZMVWBNQSA-N
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Search PubMed clinical trials spirapril
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Search PubMed titles/abstracts spirapril
Search UniChem for chemical match using the InChIKey HRWCVUIFMSZDJS-SZMVWBNQSA-N
Search UniChem for chemicals with the same backbone HRWCVUIFMSZDJS
Wikipedia Spirapril
Comments
ACE inhibitor prodrug metabolised to spiraprilat