tacrine   Click here for help

GtoPdb Ligand ID: 6687

Synonyms: CI-970 | Cognex® | tetrahydroaminoacridine
Approved drug PDB Ligand
tacrine is an approved drug (FDA (1993))
Compound class: Synthetic organic
Comment: Tacrine is a dual inhibitor of butyrylcholine esterase (P06276) and acetylcholinesterase (P22303). Marketed formulations may contain tacrine hydrochloride (PubChem CID 2723754).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 38.91
Molecular weight 198.12
XLogP 2.23
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES Nc1c2CCCCc2nc2c1cccc2
Isomeric SMILES Nc1c2CCCCc2nc2c1cccc2
InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
InChI Key YLJREFDVOIBQDA-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1993))
IUPAC Name Click here for help
1,2,3,4-tetrahydroacridin-9-amine
International Nonproprietary Names Click here for help
INN number INN
800 tacrine
Synonyms Click here for help
CI-970 | Cognex® | tetrahydroaminoacridine
Database Links Click here for help
Specialist databases
GPCRdb Ligand tacrine
Reactome Drug Reactome logo R-ALL-9635024
Reactome Reaction Reactome logo R-HSA-9634834
Other databases
CAS Registry No. 321-64-2
ChEBI CHEBI:45980
ChEMBL Ligand CHEMBL95
DrugBank Ligand DB00382
DrugCentral Ligand 2551
GtoPdb PubChem SID 178103299
PubChem CID 1935
RCSB PDB Ligand THA
Search Google for chemical match using the InChIKey YLJREFDVOIBQDA-UHFFFAOYSA-N
Search Google for chemicals with the same backbone YLJREFDVOIBQDA
Search PubMed clinical trials tacrine
Search PubMed titles tacrine
Search PubMed titles/abstracts tacrine
SynPHARM 78671 (in complex with butyrylcholinesterase)
UniChem Compound Search for chemical match using the InChIKey YLJREFDVOIBQDA-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey YLJREFDVOIBQDA-UHFFFAOYSA-N
Wikipedia Tacrine